An updated version of the Princess2 protocol was published today. The updates are minor but they clarify and simplify some of the procedures such as randomization and neuroprognostication.Â
Please update your investigator site files with the new version – note SUPERCEDED on the old version and store it in the back of your site file.Â
✅ Expanded Steering Committee
✅ Expanded Advisory/Support Group
✅ Clarified version tracking section
✅ Randomization procedure clarified to be performed using sealed envelopes instead of a digital randomization system
✅ Specified that neuroprognostication is not required for participants who are awake at 72 hours
✅ Minor editorial and formatting revisions throughout the document